Two distinct forms of human BLT2: long-form and short-form BLT2

Jun-Dong Wei; Jae-Hong Kim

doi:10.3389/fcell.2023.1288373

Two distinct forms of human BLT2: long-form and short-form BLT2

Front Cell Dev Biol. 2023 Oct 26:11:1288373. doi: 10.3389/fcell.2023.1288373. eCollection 2023.

Authors

Jun-Dong Wei^#¹, Jae-Hong Kim^#²

Affiliations

¹ Department of Basic Medical Science, Medical College, Taizhou University, Taizhou, China.
² Division of Life Sciences, College of Life Sciences, Korea University, Seoul, Republic of Korea.

^# Contributed equally.

Abstract

BLT2 is a low-affinity leukotriene B₄ receptor that plays an essential role in the pathogenesis of various inflammatory diseases, including asthma and cancer. BLT2 is minimally expressed in a normal internal environment but is overexpressed in a stress-induced inflammatory environment. Recent research indicated that human BLT2 has two distinct forms. Although their functions are likely to be different, very few studies investigated these differences. Therefore, this paper will discuss about the two distinct forms of human BLT2; the short-form of BLT2 and the long-form of BLT2.

Keywords: BLT2; G protein-coupled receptor; N-terminal domain; leukotriene B4; lipid mediator.

Publication types

Review

Grants and funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.