The adhesin SCF1 mediates Candida auris colonization

Abishek Balakumar; Douglas Bernstein; Shankar Thangamani

doi:10.1016/j.tim.2023.10.008

The adhesin SCF1 mediates Candida auris colonization

Trends Microbiol. 2024 Jan;32(1):4-5. doi: 10.1016/j.tim.2023.10.008. Epub 2023 Nov 9.

Authors

Abishek Balakumar¹, Douglas Bernstein², Shankar Thangamani³

Affiliations

¹ Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47906, USA.
² Department of Biology, Ball State University, Muncie, IN 47306, USA.
³ Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47906, USA; Purdue Institute for Immunology, Inflammation, and Infectious Diseases (PI4D), Purdue University, West Lafayette, IN 47906, USA. Electronic address: sthangam@purdue.edu.

PMID: 37951769
PMCID: PMC10872899 (available on 2025-01-01)
DOI: 10.1016/j.tim.2023.10.008

Abstract

Candida auris is an emerging human fungal pathogen that can rapidly spread and cause outbreaks of invasive infections. Santana et al. discovered that a novel surface colonization factor (SCF1), and a conserved adhesin, Iff4109, mediates C. auris colonization on abiotic surfaces, skin, and virulence in vivo.

Keywords: C. auris; biofilm formation; colonization; surface colonization factor; virulence.

MeSH terms

Adhesins, Bacterial
Antifungal Agents
Candida auris
Candida*
Candidiasis* / microbiology
Humans
Virulence

Substances

Adhesins, Bacterial
Antifungal Agents

Grants and funding

R01 AI177604/AI/NIAID NIH HHS/United States