Resorbable barrier polymers for flexible bioelectronics

Samantha M McDonald; Quansan Yang; Yen-Hao Hsu; Shantanu P Nikam; Ziying Hu; Zilu Wang; Darya Asheghali; Tiffany Yen; Andrey V Dobrynin; John A Rogers; Matthew L Becker

doi:10.1038/s41467-023-42775-5

Resorbable barrier polymers for flexible bioelectronics

Nat Commun. 2023 Nov 11;14(1):7299. doi: 10.1038/s41467-023-42775-5.

Authors

Samantha M McDonald¹, Quansan Yang^{2

3}, Yen-Hao Hsu¹, Shantanu P Nikam¹, Ziying Hu³, Zilu Wang⁴, Darya Asheghali¹, Tiffany Yen¹, Andrey V Dobrynin⁴, John A Rogers^{5

6

7

8}, Matthew L Becker^{9

10

11

12}

Affiliations

¹ Department of Chemistry, Duke University, Durham, NC, 27708, USA.
² Department of Mechanical Engineering, Northwestern University, Evanston, IL, 60208, USA.
³ Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60208, USA.
⁴ Department of Chemistry, University of North Carolina-Chapel Hill, Chapel Hill, NC, 27599, USA.
⁵ Department of Mechanical Engineering, Northwestern University, Evanston, IL, 60208, USA. jrogers@northwestern.edu.
⁶ Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60208, USA. jrogers@northwestern.edu.
⁷ Department of Biomedical Engineering and Neurological Surgery, Northwestern University, Evanston, IL, 60208, USA. jrogers@northwestern.edu.
⁸ Department of Materials Science and Engineering, Northwestern University, Evanston, IL, 60208, USA. jrogers@northwestern.edu.
⁹ Department of Chemistry, Duke University, Durham, NC, 27708, USA. matthew.l.becker@duke.edu.
¹⁰ Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708, USA. matthew.l.becker@duke.edu.
¹¹ Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA. matthew.l.becker@duke.edu.
¹² Department of Orthopedic Surgery, Duke University, Durham, NC, 27708, USA. matthew.l.becker@duke.edu.

Abstract

Resorbable, implantable bioelectronic devices are emerging as powerful tools to reliably monitor critical physiological parameters in real time over extended periods. While degradable magnesium-based electronics have pioneered this effort, relatively short functional lifetimes have slowed clinical translation. Barrier films that are both flexible and resorbable over predictable timelines would enable tunability in device lifetime and expand the viability of these devices. Herein, we present a library of stereocontrolled succinate-based copolyesters which leverage copolymer composition and processing method to afford tunability over thermomechanical, crystalline, and barrier properties. One copolymer composition within this library has extended the functional lifetime of transient bioelectronic prototypes over existing systems by several weeks-representing a considerable step towards translational devices.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't

MeSH terms

Electronics*
Polymers* / chemistry

Substances

Polymers

Grants and funding

P30 CA060553/CA/NCI NIH HHS/United States