Understanding the Basis for Hyperemic and Nonhyperemic Coronary Pressure Assessment

Cardiol Clin. 2024 Feb;42(1):1-11. doi: 10.1016/j.ccl.2023.07.012.

Abstract

Despite the now routine integration of invasive physiologic systems into coronary catheter laboratories worldwide, it remains critical that all operators maintain a sound understanding of the fundamental physiologic basis for coronary pressure assessment. More specifically, performing operators should be well informed regarding the basis for hyperemic (ie, fractional flow reserve) and nonhyperemic (ie, instantaneous wave-free ratio and other nonhyperemic pressure ratio) coronary pressure assessment. In this article, we provide readers a comprehensive history charting the inception, development, and validation of hyperemic and nonhyperemic coronary pressure assessment.

Keywords: Coronary flow; FFR; Hyperemia; NHPR; iFR.

Publication types

  • Review

MeSH terms

  • Cardiac Catheterization
  • Coronary Angiography
  • Coronary Stenosis*
  • Coronary Vessels
  • Fractional Flow Reserve, Myocardial* / physiology
  • Humans
  • Hyperemia*
  • Predictive Value of Tests
  • Severity of Illness Index