Youth-associated platelet-derived chemokine reverses brain aging through neuroimmune mechanisms

Brittany M Hemmer; Sarah M Philippi; Joseph M Castellano

doi:10.1016/j.molmed.2023.10.007

Youth-associated platelet-derived chemokine reverses brain aging through neuroimmune mechanisms

Trends Mol Med. 2024 Jan;30(1):10-12. doi: 10.1016/j.molmed.2023.10.007. Epub 2023 Nov 7.

Authors

Brittany M Hemmer¹, Sarah M Philippi¹, Joseph M Castellano²

Affiliations

¹ Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
² Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: joseph.castellano@mssm.edu.

PMID: 37945435
PMCID: PMC10872830 (available on 2025-01-01)
DOI: 10.1016/j.molmed.2023.10.007

Abstract

Age-related loss of brain function has been seen as inevitable, yet recent work leveraging the systemic environment challenges this notion. Schroer et al. demonstrate that youth-associated platelet factor 4 (PF4) partially restores brain function in aged mice while reducing peripheral immune dysfunction, supporting periphery-based approaches to treat age-associated brain disorders.

Keywords: aging; hippocampus; platelets; rejuvenation; young blood.

MeSH terms

Adolescent
Aging
Animals
Blood Platelets / metabolism
Brain* / metabolism
Chemokines / metabolism
Humans
Mice
Neuroimmunomodulation*

Substances

Chemokines

Abstract

MeSH terms

Substances

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