Benzylisoquinoline alkaloids with their antitumor activity from the aerial parts of Corydalis impatiens (pall.) Fisch

Ze-Dong Nan; Yi-Dong Zhu; Chao-Fan Deng; Guo-Dong Jiang; Zhen-Zhen Wang; Chong-Long Li; Xiao-Li Ma; Zhi-Bo Jiang

doi:10.1016/j.fitote.2023.105738

Benzylisoquinoline alkaloids with their antitumor activity from the aerial parts of Corydalis impatiens (pall.) Fisch

Fitoterapia. 2024 Jan:172:105738. doi: 10.1016/j.fitote.2023.105738. Epub 2023 Nov 7.

Authors

Ze-Dong Nan¹, Yi-Dong Zhu², Chao-Fan Deng², Guo-Dong Jiang², Zhen-Zhen Wang², Chong-Long Li², Xiao-Li Ma², Zhi-Bo Jiang³

Affiliations

¹ Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, and Key Laboratory of Chemical Engineering and Technology of State Ethnic Affairs Commission, North Minzu University, Yinchuan 750021, PR China; Ningxia low-grade resource high value utilization and environmental chemical integration technology innovation team project, Yinchuan 750021, PR China.
² Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, and Key Laboratory of Chemical Engineering and Technology of State Ethnic Affairs Commission, North Minzu University, Yinchuan 750021, PR China.
³ Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, and Key Laboratory of Chemical Engineering and Technology of State Ethnic Affairs Commission, North Minzu University, Yinchuan 750021, PR China; Ningxia low-grade resource high value utilization and environmental chemical integration technology innovation team project, Yinchuan 750021, PR China. Electronic address: j836811@163.com.

PMID: 37939736
DOI: 10.1016/j.fitote.2023.105738

Abstract

Phytochemical investigation on the aerial parts of Corydalis impatiens (pall.) Fisch (Papaveraceae) resulted in the identification of four previous undescribed benzylisoquinoline alkaloids, impatienines A-D (1-4), together with 14 known analogues (5-18). The structures of these compounds were elucidated by extensive spectroscopic analysis (IR, HR-ESIMS, 1D- and 2D-NMR) as well as ECD calculations. All the compounds obtained were investigated for their inhibitory effect on the growth of A549, H1299 and HepG2 cancer cells. Compounds 7 and 15 exhibited pronounced inhibition against the A549 cancer cells with IC₅₀ values of 6.81 μM and 3.17 μM, while the positive control cisplatin was 1.83 μM. Compounds 1-3 showed moderate inhibitory on the H1299 cancer cells. Compounds 4, 10-12, and 16 showed signiffcant activity against HepG2 cancer cells with IC₅₀ values range of 4.41-8.75 μM.

Keywords: Alkaloid; Antitumor activity; Benzylisoquinoline; Corydalis impatiens (pall.) Fisch; Papaveraceae.

MeSH terms

Alkaloids* / chemistry
Benzylisoquinolines*
Corydalis* / chemistry
Impatiens*
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Components, Aerial / chemistry

Substances

Benzylisoquinolines
Alkaloids