Regenerating the heart by metabolically reprogramming the cardiomyocyte epigenome

Xiaoqiang Tang

doi:10.1016/j.cmet.2023.10.007

Regenerating the heart by metabolically reprogramming the cardiomyocyte epigenome

Cell Metab. 2023 Nov 7;35(11):1849-1851. doi: 10.1016/j.cmet.2023.10.007.

Author

Xiaoqiang Tang¹

Affiliation

¹ Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, No.17 People's South Road, Chengdu, Sichuan 610041, China; National Health Commission Key Laboratory of Chronobiology, Sichuan University, No.17 People's South Road, Chengdu, Sichuan 610041, China; Development and Related Diseases of Women and Children, Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, No.17 People's South Road, Chengdu, Sichuan 610041, China. Electronic address: tangxiaoqiang@scu.edu.cn.

PMID: 37939655
DOI: 10.1016/j.cmet.2023.10.007

Abstract

In mammal adolescence, cardiomyocytes rapidly exit the cell cycle, and heart regeneration in adults is limited after cardiac injury. Recent work by Li et al. in Nature revealed that inhibition of fatty acid oxidation can rewire cell metabolism and lead to epigenetic reprogramming of cardiomyocytes to an immature state that facilitates cardiomyocyte cell-cycle reentry and heart regeneration in adult animals.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Cycle
Cell Division
Cell Proliferation
Epigenome*
Heart / physiology
Mammals
Myocytes, Cardiac* / metabolism
Regeneration / genetics