Discovery of plant-derived anti-tumor natural products: Potential leads for anti-tumor drug discovery

Zi Hui; Hao Wen; Junlong Zhu; Haowen Deng; Xiaoying Jiang; Xiang-Yang Ye; Liwei Wang; Tian Xie; Renren Bai

doi:10.1016/j.bioorg.2023.106957

Discovery of plant-derived anti-tumor natural products: Potential leads for anti-tumor drug discovery

Bioorg Chem. 2024 Jan:142:106957. doi: 10.1016/j.bioorg.2023.106957. Epub 2023 Nov 4.

Authors

Zi Hui¹, Hao Wen¹, Junlong Zhu¹, Haowen Deng¹, Xiaoying Jiang¹, Xiang-Yang Ye¹, Liwei Wang², Tian Xie³, Renren Bai⁴

Affiliations

¹ School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China; Key Laboratory of Elemene Class Anti-tumor Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China.
² School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China; Key Laboratory of Elemene Class Anti-tumor Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China. Electronic address: wangliwei78@163.com.
³ School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China; Key Laboratory of Elemene Class Anti-tumor Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China. Electronic address: xbs@hznu.edu.cn.
⁴ School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China; Key Laboratory of Elemene Class Anti-tumor Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China. Electronic address: renrenbai@hznu.edu.cn.

PMID: 37939507
DOI: 10.1016/j.bioorg.2023.106957

Abstract

Natural products represent a paramount source of novel drugs. Numerous plant-derived natural products have demonstrated potent anti-tumor properties, thereby garnering considerable interest in their potential as anti-tumor drugs. This review compiles an overview of 242 recently discovered natural products, spanning the period from 2018 to the present. These natural products, which include 69 terpenoids, 42 alkaloids, 39 flavonoids, 21 steroids, 14 phenylpropanoids, 5 quinolines and 52 other compounds, are characterized by their respective chemical structures, anti-tumor activities, and mechanisms of action. By providing an essential reference and fresh insights, this review aims to support and inspire researchers engaged in the fields of natural products and anti-tumor drug discovery.

Keywords: Anti-tumor; Drug discovery; Natural products; Plants.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids* / chemistry
Alkaloids* / pharmacology
Antineoplastic Agents* / pharmacology
Biological Products* / chemistry
Biological Products* / pharmacology
Flavonoids / chemistry
Plants / chemistry

Substances

Biological Products
Alkaloids
Flavonoids
Antineoplastic Agents