A case of acute recurrent pancreatitis caused by biliopancreatic reflux without pancreaticobiliary maljunction

Clin J Gastroenterol. 2024 Feb;17(1):183-187. doi: 10.1007/s12328-023-01875-x. Epub 2023 Nov 8.

Abstract

Acute recurrent pancreatitis (ARP) is a clinical condition characterized by repeated episodes of acute pancreatitis. In this case study, a 62-year-old man was diagnosed with mild pancreatitis five years ago, with alcohol intake initially considered the cause. Since then, he experienced three episodes of pancreatitis despite ceasing alcohol consumption completely. Consequently, the patient was diagnosed with ARP. Various diagnostic and imaging tests were performed to determine the etiology of his condition, including blood tests, magnetic resonance cholangiopancreatography, endoscopic ultrasonography, and contrast-enhanced computed tomography. The results were inconclusive; however, endoscopic retrograde cholangiopancreatography revealed the reflux of bile and pancreatic juice into the alternative ducts, despite the absence of anatomical abnormalities in the biliary tract or pancreatic duct. These findings subsequently led to the diagnosis of biliopancreatic reflux, which activated pancreatic enzymes causing ARP. Endoscopic biliary sphincterotomy was performed to alleviate the patient's symptoms. One year later, the patient remained symptom-free. This case highlights the importance of examining bile and pancreatic juice components before considering endoscopic sphincterotomy in patients with unexplained ARP.

Keywords: Endoscopic biliary sphincterotomy; Endoscopic retrograde cholangiopancreatography; Pancreatitis.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Cholangiopancreatography, Endoscopic Retrograde / methods
  • Humans
  • Male
  • Middle Aged
  • Pancreatic Ducts / diagnostic imaging
  • Pancreatic Ducts / pathology
  • Pancreaticobiliary Maljunction* / complications
  • Pancreatitis* / diagnostic imaging
  • Pancreatitis* / etiology