Engineering metabolism to modulate immunity

Senta M Kapnick; Corinne A Martin; Christopher M Jewell

doi:10.1016/j.addr.2023.115122

Engineering metabolism to modulate immunity

Adv Drug Deliv Rev. 2024 Jan:204:115122. doi: 10.1016/j.addr.2023.115122. Epub 2023 Nov 5.

Authors

Senta M Kapnick¹, Corinne A Martin², Christopher M Jewell³

Affiliations

¹ Fischell Department of Bioengineering, University of Maryland, 8278 Paint Branch Drive, College Park, MD, USA; Department of Veterans Affairs, VA Maryland Health Care System, 10 N Green Street, Baltimore, MD, USA.
² Fischell Department of Bioengineering, University of Maryland, 8278 Paint Branch Drive, College Park, MD, USA.
³ Fischell Department of Bioengineering, University of Maryland, 8278 Paint Branch Drive, College Park, MD, USA; Department of Veterans Affairs, VA Maryland Health Care System, 10 N Green Street, Baltimore, MD, USA; Robert E. Fischell Institute for Biomedical Devices, 8278 Paint Branch Drive, College Park, MD, USA; Marlene and Stewart Greenebaum Comprehensive Cancer Center, 22 S Greene Street, Suite N9E17, Baltimore, MD, USA. Electronic address: cmjewell@umd.edu.

PMID: 37935318
PMCID: PMC10843796 (available on 2025-01-01)
DOI: 10.1016/j.addr.2023.115122

Abstract

Metabolic programming and reprogramming have emerged as pivotal mechanisms for altering immune cell function. Thus, immunometabolism has become an attractive target area for treatment of immune-mediated disorders. Nonetheless, many hurdles to delivering metabolic cues persist. In this review, we consider how biomaterials are poised to transform manipulation of immune cell metabolism through integrated control of metabolic configurations to affect outcomes in autoimmunity, regeneration, transplant, and cancer. We emphasize the features of nanoparticles and other biomaterials that permit delivery of metabolic cues to the intracellular compartment of immune cells, or strategies for altering signals in the extracellular space. We then provide perspectives on the potential for reciprocal regulation of immunometabolism by the physical properties of materials themselves. Lastly, opportunities for clinical translation are highlighted. This discussion contributes to our understanding of immunometabolism, biomaterials-based strategies for altering metabolic configurations in immune cells, and emerging concepts in this evolving field.

Keywords: Biomaterials; Immune engineering; Immunometabolism.

Publication types

Review

MeSH terms

Biocompatible Materials*
Humans
Neoplasms* / therapy

Substances

Biocompatible Materials

Abstract

Publication types

MeSH terms

Substances

Grants and funding