The 2022 Banff Meeting Lung Report

Elizabeth N Pavlisko; Benjamin A Adam; Gerald J Berry; Fiorella Calabrese; Nahir Cortes-Santiago; Carolyn H Glass; Martin Goddard; John R Greenland; Daniel Kreisel; Deborah J Levine; Tereza Martinu; Stijn E Verleden; S Sam Weigt; Antoine Roux

doi:10.1016/j.ajt.2023.10.022

The 2022 Banff Meeting Lung Report

Am J Transplant. 2024 Apr;24(4):542-548. doi: 10.1016/j.ajt.2023.10.022. Epub 2023 Nov 4.

Authors

Affiliations

¹ Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA. Electronic address: elizabeth.pavlisko@duke.edu.
² Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
³ Department of Pathology, Stanford University, Stanford, California, USA.
⁴ Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, Padova, Italy.
⁵ Department of Pathology and Immunology, Texas Children's Hospital, Houston, Texas, USA.
⁶ Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
⁷ Pathology Department, Royal Papworth Hospital, NHS Trust, Papworth Everard, Cambridge, UK.
⁸ Department of Medicine, University of California, San Francisco, USA; Veterans Affairs Health Care System, San Francisco, California, USA.
⁹ Department of Surgery, Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.
¹⁰ Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, California, USA.
¹¹ Division of Respirology, Department of Medicine, University Health Network and University of Toronto, Toronto, Ontario, Canada; Toronto Lung Transplant Program, University Health Network, Toronto, Ontario, Canada.
¹² Lung Transplant Unit, Department of Chronic Diseases and Metabolism, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium; Department of ASTARC, University of Antwerp, Wilrijk, Belgium.
¹³ Division of Pulmonary, Allergy, and Critical Care Medicine, University of California Los Angeles, Los Angeles, California, USA.
¹⁴ Department of Respiratory Medicine, Foch Hospital, Suresnes, France.

PMID: 37931751
DOI: 10.1016/j.ajt.2023.10.022

Abstract

The Lung Session of the 2022 16th Banff Foundation for Allograft Pathology Conference-held in Banff, Alberta-focused on non-rejection lung allograft pathology and novel technologies for the detection of allograft injury. A multidisciplinary panel reviewed the state-of-the-art of current histopathologic entities, serologic studies, and molecular practices, as well as novel applications of digital pathology with artificial intelligence, gene expression analysis, and quantitative image analysis of chest computerized tomography. Current states of need as well as prospective integration of the aforementioned tools and technologies for complete assessment of allograft injury and its impact on lung transplant outcomes were discussed. Key conclusions from the discussion were: (1) recognition of limitations in current standard of care assessment of lung allograft dysfunction; (2) agreement on the need for a consensus regarding the standardized approach to the collection and assessment of pathologic data, inclusive of all lesions associated with graft outcome (eg, non-rejection pathology); and (3) optimism regarding promising novel diagnostic modalities, especially minimally invasive, which should be integrated into large, prospective multicenter studies to further evaluate their utility in clinical practice for directing personalized therapies to improve graft outcomes.

Keywords: artificial intelligence; lung transplantation; molecular; pathology.

MeSH terms

Artificial Intelligence*
Biopsy
Graft Rejection* / diagnosis
Graft Rejection* / etiology
Lung
Prospective Studies
Transplantation, Homologous