Combination treatment with monoclonal antibodies: Dupilumab and ustekinumab for the treatment of severe atopic dermatitis and Crohn disease

Australas J Dermatol. 2024 Feb;65(1):63-66. doi: 10.1111/ajd.14185. Epub 2023 Nov 6.

Abstract

Evidence of effectiveness and safety in combined therapies is scarce and based on case reports and small case series. We report a case of dual biologic therapy with ustekinumab and dupilumab in a patient with severe Crohn disease and atopic dermatitis. There was no interference between these drugs after a 7-month follow-up.

Keywords: atopic dermatitis; biologic treatment; combined therapies; dupilumab; monoclonal antibodies; ustekinumab.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • Antibodies, Monoclonal, Humanized*
  • Crohn Disease* / drug therapy
  • Dermatitis, Atopic* / drug therapy
  • Humans
  • Severity of Illness Index
  • Treatment Outcome
  • Ustekinumab / therapeutic use

Substances

  • Antibodies, Monoclonal
  • dupilumab
  • Ustekinumab
  • Antibodies, Monoclonal, Humanized