Shared genetic architecture of COVID-19 and Alzheimer's disease

Natalia Matveeva; Ivan Kiselev; Natalia Baulina; Ekaterina Semina; Viktor Kakotkin; Mikhail Agapov; Olga Kulakova; Olga Favorova

doi:10.3389/fnagi.2023.1287322

Shared genetic architecture of COVID-19 and Alzheimer's disease

Front Aging Neurosci. 2023 Oct 20:15:1287322. doi: 10.3389/fnagi.2023.1287322. eCollection 2023.

Authors

Natalia Matveeva^{1

2}, Ivan Kiselev^{1

2}, Natalia Baulina^{1

2}, Ekaterina Semina¹, Viktor Kakotkin¹, Mikhail Agapov¹, Olga Kulakova^{1

2}, Olga Favorova^{1

2}

Affiliations

¹ Institute of Medicine and Life Science, Immanuel Kant Baltic Federal University, Kaliningrad, Russia.
² Laboratory of Medical Genomics, Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russia.

Abstract

The severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and the сoronavirus disease 2019 (COVID-19) have become a global health threat. At the height of the pandemic, major efforts were focused on reducing COVID-19-associated morbidity and mortality. Now is the time to study the long-term effects of the pandemic, particularly cognitive impairment associated with long COVID. In recent years much attention has been paid to the possible relationship between COVID-19 and Alzheimer's disease, which is considered a main cause of age-related cognitive impairment. Genetic predisposition was shown for both COVID-19 and Alzheimer's disease. However, the analysis of the similarity of the genetic architecture of these diseases is usually limited to indicating a positive genetic correlation between them. In this review, we have described intrinsic linkages between COVID-19 and Alzheimer's disease, pointed out shared susceptibility genes that were previously identified in genome-wide association studies of both COVID-19 and Alzheimer's disease, and highlighted a panel of SNPs that includes candidate genetic risk markers of the long COVID-associated cognitive impairment.

Keywords: Alzheimer’s disease; COVID-19; GWAS; SNP; cognitive impairment; genetic susceptibility; long Covid; pathway analysis.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was supported from the Russian Federal Academic Leadership Program Priority 2030 at the Immanuel Kant Baltic Federal University.