Associations between recall of proper names in story recall and CSF amyloid and tau in adults without cognitive impairment

Madeline R Hale; Rebecca Langhough; Lianlian Du; Bruce P Hermann; Carol A Van Hulle; Margherita Carboni; Gwendlyn Kollmorgen; Kristin E Basche; Davide Bruno; Leah Sanson-Miles; Erin M Jonaitis; Nathaniel A Chin; Ozioma C Okonkwo; Barbara B Bendlin; Cynthia M Carlsson; Henrik Zetterberg; Kaj Blennow; Tobey J Betthauser; Sterling C Johnson; Kimberly D Mueller

doi:10.1016/j.neurobiolaging.2023.09.018

Associations between recall of proper names in story recall and CSF amyloid and tau in adults without cognitive impairment

Neurobiol Aging. 2024 Jan:133:87-98. doi: 10.1016/j.neurobiolaging.2023.09.018. Epub 2023 Oct 5.

Authors

Madeline R Hale¹, Rebecca Langhough², Lianlian Du³, Bruce P Hermann⁴, Carol A Van Hulle⁵, Margherita Carboni⁶, Gwendlyn Kollmorgen⁷, Kristin E Basche⁸, Davide Bruno⁹, Leah Sanson-Miles¹, Erin M Jonaitis², Nathaniel A Chin¹⁰, Ozioma C Okonkwo¹¹, Barbara B Bendlin¹⁰, Cynthia M Carlsson¹², Henrik Zetterberg¹³, Kaj Blennow¹⁴, Tobey J Betthauser¹⁵, Sterling C Johnson¹⁰, Kimberly D Mueller¹⁶

Affiliations

¹ Department of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, WI, USA.
² Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
³ School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
⁴ Department of Neurology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
⁵ Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA.
⁶ Roche Diagnostics International Ltd, Rotkreuz, Switzerland.
⁷ Roche Diagnostics GmbH, Penzberg, Germany.
⁸ Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
⁹ School of Psychology, Liverpool John Moores University, Liverpool, UK.
¹⁰ Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA; VA Geriatric Research, Education and Clinical Center (GRECC), William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
¹¹ School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
¹² Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA.
¹³ Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; UK Dementia Research Institute at UCL, London, UK; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
¹⁴ Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
¹⁵ Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA.
¹⁶ Department of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, WI, USA; Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA. Electronic address: kdmueller@wisc.edu.

PMID: 37925995
PMCID: PMC10842469 (available on 2025-01-01)
DOI: 10.1016/j.neurobiolaging.2023.09.018

Abstract

Neuropsychological measures sensitive to decline in the preclinical phase of Alzheimer's disease are needed. We previously demonstrated that higher amyloid-beta (Aβ) assessed by positron emission tomography in adults without cognitive impairment was associated with recall of fewer proper names in Logical Memory story recall. The current study investigated the association between proper names and cerebrospinal fluid biomarkers (Aβ_42/40, phosphorylated tau₁₈₁ [pTau₁₈₁], neurofilament light) in 223 participants from the Wisconsin Registry for Alzheimer's Prevention. We assessed associations between biomarkers and delayed Logical Memory total score and proper names using binary logistic regressions. Sensitivity analyses used multinomial logistic regression and stratified biomarker groups. Lower Logical Memory total score and proper names scores from the most recent visit were associated with biomarker positivity. Relatedly, there was a 27% decreased risk of being classified Aβ_42/40+/pTau₁₈₁+ for each additional proper name recalled. A linear mixed effects model found that longitudinal change in proper names recall was predicted by biomarker status. These results demonstrate a novel relationship between proper names and Alzheimer's disease-cerebrospinal fluid pathology.

Keywords: Cerebrospinal fluid; Early detection; Preclinical Alzheimer’s disease; Proper names; Story recall.

MeSH terms

Alzheimer Disease* / pathology
Amyloid beta-Peptides / cerebrospinal fluid
Biomarkers / cerebrospinal fluid
Cognitive Dysfunction* / psychology
Disease Progression
Humans
Longitudinal Studies
Peptide Fragments / cerebrospinal fluid
tau Proteins / cerebrospinal fluid

Substances

tau Proteins
Amyloid beta-Peptides
Biomarkers
Peptide Fragments

Abstract

MeSH terms

Substances

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