Generation of the induced pluripotent stem cell line ESi108-A from a familial atrial fibrillation patient

Stem Cell Res. 2023 Dec:73:103239. doi: 10.1016/j.scr.2023.103239. Epub 2023 Oct 31.

Abstract

Tissue-specific cells differentiated from patient-derived human induced pluripotent stem cells (hiPSC) are a relevant cellular model to study several diseases. We obtained a hiPSC line from skin fibroblasts of a patient affected by familial atrial fibrillation by nucleofection of non-integrating episomal vectors. The resulting hiPSC line displays a normal karyotype, expresses pluripotency surface markers and pluripotency genes, and differentiates into cells of the 3 germ layers. Therefore, it represents a reliable model to study the disease in a physiologically relevant cellular environment.

MeSH terms

  • Atrial Fibrillation* / genetics
  • Atrial Fibrillation* / metabolism
  • Cell Differentiation
  • Cell Line
  • Humans
  • Induced Pluripotent Stem Cells* / metabolism
  • Plasmids