Interactions between neutrophils and T-helper 17 cells

Xinzou Fan; Panyin Shu; Ying Wang; Ning Ji; Dunfang Zhang

doi:10.3389/fimmu.2023.1279837

Interactions between neutrophils and T-helper 17 cells

Front Immunol. 2023 Oct 18:14:1279837. doi: 10.3389/fimmu.2023.1279837. eCollection 2023.

Authors

Xinzou Fan¹, Panyin Shu¹, Ying Wang², Ning Ji², Dunfang Zhang¹

Affiliations

¹ Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
² State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Abstract

Neutrophils comprise the majority of immune cells in human peripheral circulation, have potent antimicrobial activities, and are clinically significant in their abundance, heterogeneity, and subcellular localization. In the past few years, the role of neutrophils as components of the innate immune response has been studied in numerous ways, and these cells are crucial in fighting infections, autoimmune diseases, and cancer. T-helper 17 (Th17) cells that produce interleukin 17 (IL-17) are critical in fighting infections and maintaining mucosal immune homeostasis, whereas they mediate several autoimmune diseases. Neutrophils affect adaptive immune responses by interacting with adaptive immune cells. In this review, we describe the physiological roles of both Th17 cells and neutrophils and their interactions and briefly describe the pathological processes in which these two cell types participate. We provide a summary of relevant drugs targeting IL-17A and their clinical trials. Here, we highlight the interactions between Th17 cells and neutrophils in diverse pathophysiological situations.

Keywords: T-helper 17 cells; autoimmune diseases; interleukin-17; neutrophil extracellular traps (NETs); neutrophils.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Autoimmune Diseases*
Humans
Immunity, Innate
Neutrophils*
Th17 Cells

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (NO. 82171829), the Key Project of the Science and Technology Department of Sichuan Province (NO. 2022YFH0100, 2022YFS0003), the 1·3·5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (NO. ZYYC21012), and Fundamental Research Funds for Central Universities (20822041E4084).