Acquired Factor VII Deficiency Associated With Chronic Myeloid Leukemia Blast Crisis

J Investig Med High Impact Case Rep. 2023 Jan-Dec:11:23247096231209543. doi: 10.1177/23247096231209543.

Abstract

Factor VII (FVII) is an important, vitamin K-dependent clotting factor. Acquired FVII deficiency is a rare entity that is associated with serious bleeding complications. We report a case of acquired FVII deficiency in a patient with recurrent chronic myeloid leukemia in blast crisis who developed bilateral retinal hemorrhages. The coagulopathy was corrected with the initiation of chemotherapy and subsequent reduction in peripheral blast count.

Keywords: Factor VII deficiency; blast crisis; chronic myeloid leukemia; hematopoietic stem cell transplant; retinal hemorrhage.

Publication types

  • Case Reports

MeSH terms

  • Blast Crisis / complications
  • Blast Crisis / drug therapy
  • Factor VII / therapeutic use
  • Factor VII Deficiency* / complications
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / complications
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / drug therapy
  • Vitamin K / therapeutic use

Substances

  • Factor VII
  • Vitamin K