Differential Effects of HLA-B∗15:11 and HLA-A∗31:01 on Carbamazepine-Induced Cutaneous Adverse Reactions

Koya Fukunaga; Eri Tsukagoshi; Maiko Kurata; Yoshiko Mizukawa; Hiroyuki Niihara; Eishin Morita; Yuko Watanabe; Yukie Yamaguchi; Hideaki Watanabe; Saeko Nakajima; Takashi Nomura; Kenji Kabashima; Mikiko Tohyama; Hiroaki Azukizawa; Hideo Asada; Akito Hasegawa; Natsumi Hama; Takeshi Ozeki; Yoichi Mashimo; Akihiro Sekine; Kayoko Matsunaga; Yoichi Tanaka; Ryosuke Nakamura; Riichiro Abe; Taisei Mushiroda; Yoshiro Saito

doi:10.1016/j.jid.2023.09.282

Differential Effects of HLA-B∗15:11 and HLA-A∗31:01 on Carbamazepine-Induced Cutaneous Adverse Reactions

J Invest Dermatol. 2024 Apr;144(4):908-911.e7. doi: 10.1016/j.jid.2023.09.282. Epub 2023 Oct 30.

Authors

Koya Fukunaga¹, Eri Tsukagoshi², Maiko Kurata³, Yoshiko Mizukawa³, Hiroyuki Niihara⁴, Eishin Morita⁴, Yuko Watanabe⁵, Yukie Yamaguchi⁵, Hideaki Watanabe⁶, Saeko Nakajima⁷, Takashi Nomura⁷, Kenji Kabashima⁷, Mikiko Tohyama⁸, Hiroaki Azukizawa⁹, Hideo Asada⁹, Akito Hasegawa¹⁰, Natsumi Hama¹⁰, Takeshi Ozeki¹¹, Yoichi Mashimo¹², Akihiro Sekine¹², Kayoko Matsunaga¹³, Yoichi Tanaka², Ryosuke Nakamura², Riichiro Abe¹⁰, Taisei Mushiroda¹⁴, Yoshiro Saito²

Affiliations

¹ Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Division of Medicinal Safety Science, National Institute of Health Sciences, Kawasaki, Japan.
² Division of Medicinal Safety Science, National Institute of Health Sciences, Kawasaki, Japan.
³ Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.
⁴ Department of Dermatology, Faculty of Medicine, Shimane University, Shimane, Japan.
⁵ Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
⁶ Department of Dermatology, Showa University Northern Yokohama Hospital, Yokohama, Japan.
⁷ Department of Dermatology, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Kyoto, Japan.
⁸ Department of Dermatology, National Hospital Organization Shikoku Cancer Center, Japan.
⁹ Department of Dermatology, School of Medicine, Nara Medical University, Kashihara, Japan.
¹⁰ Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
¹¹ Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
¹² Department of Public Health, Chiba University Graduate School of Medicine, Chiba, Japan.
¹³ Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine, Nagoya, Japan.
¹⁴ Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. Electronic address: mushiroda@riken.jp.

PMID: 37914023
DOI: 10.1016/j.jid.2023.09.282

No abstract available

Keywords: Carbamazepine; Cutaneous adverse drug reaction; Genome-wide association study; HLA-A∗31:01; HLA-B∗15:11.

MeSH terms

Carbamazepine / adverse effects
Drug-Related Side Effects and Adverse Reactions*
HLA-A Antigens / genetics
HLA-B Antigens / genetics
Humans
Skin
Stevens-Johnson Syndrome*

Substances

HLA-B Antigens
Carbamazepine
HLA-A Antigens