HBHA-IGRA and cytotoxic mediators release assays for the diagnosis of cervical tuberculous lymphadenitis

Microbiol Spectr. 2023 Dec 12;11(6):e0163823. doi: 10.1128/spectrum.01638-23. Epub 2023 Nov 1.

Abstract

Cervical tuberculous lymphadenitis (CTL), the most frequent extrapulmonary form of tuberculosis, is currently a major health problem in Tunisia and in several regions around the world. CTL diagnosis is challenging mainly due to the paucibacillary nature of the disease and the potential misdiagnosis as cervical non-tuberculous lymphadenitis. This study demonstrates the added value of the heparin-binding hemagglutinin-interferon-gamma release assay as an immunoassay in the context of CTL.

Keywords: HBHA; biomarkers; cervical lymphadenitis; diagnosis; tuberculosis.

MeSH terms

  • Antineoplastic Agents*
  • Humans
  • Interferon-gamma Release Tests
  • Mycobacterium tuberculosis*
  • Tuberculosis, Lymph Node* / diagnosis
  • Tunisia

Substances

  • Antineoplastic Agents