Human emotion processing accuracy, negative biases, and fMRI activation are associated with childhood trauma

Alexis A Reisch; Katie L Bessette; Lisanne M Jenkins; Kristy A Skerrett; Laura B Gabriel; Leah R Kling; Jonathan P Stange; Kelly A Ryan; Mindy Westlund Schreiner; Sheila E Crowell; Erin A Kaufman; Scott A Langenecker

doi:10.3389/fpsyt.2023.1181785

Human emotion processing accuracy, negative biases, and fMRI activation are associated with childhood trauma

Front Psychiatry. 2023 Oct 16:14:1181785. doi: 10.3389/fpsyt.2023.1181785. eCollection 2023.

Authors

Alexis A Reisch¹, Katie L Bessette^{1

2

3}, Lisanne M Jenkins¹, Kristy A Skerrett¹, Laura B Gabriel^{1

4}, Leah R Kling¹, Jonathan P Stange⁵, Kelly A Ryan⁴, Mindy Westlund Schreiner², Sheila E Crowell^{2

6

7}, Erin A Kaufman², Scott A Langenecker^{1

3

4}

Affiliations

¹ Cognitive Neuroscience Center, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States.
² Department of Psychiatry and Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, United States.
³ Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, United States.
⁴ Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States.
⁵ Departments of Psychology and Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, CA, United States.
⁶ Department of Psychology, University of Utah, Salt Lake City, UT, United States.
⁷ Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, United States.

Abstract

Introduction: Emerging literature suggests that childhood trauma may influence facial emotion perception (FEP), with the potential to negatively bias both emotion perception and reactions to emotion-related inputs. Negative emotion perception biases are associated with a range of psychiatric and behavioral problems, potentially due or as a result of difficult social interactions. Unfortunately, there is a poor understanding of whether observed negative biases are related to childhood trauma history, depression history, or processes common to (and potentially causative of) both experiences.

Methods: The present cross-sectional study examines the relation between FEP and neural activation during FEP with retrospectively reported childhood trauma in young adult participants with remitted major depressive disorder (rMDD, n = 41) and without psychiatric histories (healthy controls [HC], n = 34). Accuracy of emotion categorization and negative bias errors during FEP and brain activation were each measured during exposure to fearful, angry, happy, sad, and neutral faces. We examined participant behavioral and neural responses in relation to total reported severity of childhood abuse and neglect (assessed with the Childhood Trauma Questionnaire, CTQ).

Results: Results corrected for multiple comparisons indicate that higher trauma scores were associated with greater likelihood of miscategorizing happy faces as angry. Activation in the right middle frontal gyrus (MFG) positively correlated with trauma scores when participants viewed faces that they correctly categorized as angry, fearful, sad, and happy.

Discussion: Identifying the neural mechanisms by which childhood trauma and MDD may change facial emotion perception could inform targeted prevention efforts for MDD or related interpersonal difficulties.

Keywords: childhood trauma; facial emotion perception; facial emotion perception test; major depressive disorder; middle frontal gyrus; response bias.

Abstract

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