A new dual functional H2S donor for fluorescence imaging and anti-inflammatory application

Shumei Huang; Zejun Li; Wenhui You; Guansheng Zheng; Huatang Zhang; Yin Jiang; Hongyan Sun

doi:10.1039/d3cc03881e

A new dual functional H₂S donor for fluorescence imaging and anti-inflammatory application

Chem Commun (Camb). 2023 Nov 16;59(92):13703-13706. doi: 10.1039/d3cc03881e.

Authors

Shumei Huang¹, Zejun Li¹, Wenhui You¹, Guansheng Zheng¹, Huatang Zhang¹, Yin Jiang¹, Hongyan Sun^{2

3}

Affiliations

¹ School of Chemical Engineering and Light Industry and School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, Guangdong, 510006, China. htzhang@gdut.edu.cn.
² Department of Chemistry and COSDAF (Centre of Super-Diamond and Advanced Films), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China. hongysun@cityu.edu.hk.
³ Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, P. R. China.

PMID: 37905349
DOI: 10.1039/d3cc03881e

Abstract

This study explored FL-H₂S, a novel fluorescein-based H₂S donor, as an anti-inflammatory agent. The results demonstrated the efficient release of H₂S by FL-H₂S, along with its biocompatibility, real-time intracellular H₂S release and imaging capability. In vivo experiments using a rat model confirmed the anti-inflammatory effects of FL-H₂S, evidenced by reduced foot swelling. We also successfully elucidated the anti-inflammatory mechanism through ELISA and WB analysis.

MeSH terms

Animals
Anti-Inflammatory Agents / pharmacology
Hydrogen Sulfide* / pharmacology
Optical Imaging
Rats

Substances

Hydrogen Sulfide
Anti-Inflammatory Agents