Neuropsychiatric Symptoms are Related to Blood-biomarkers in Major Neurocognitive Disorders

Inês Marques-Aleixo; Arnaldina Sampaio; Lucimére Bohn; Flavia Machado; Duarte Barros; Oscár Ribeiro; Joana Carvalho; José Magalhães

doi:10.2174/1874609816666230816090934

Neuropsychiatric Symptoms are Related to Blood-biomarkers in Major Neurocognitive Disorders

Curr Aging Sci. 2023 Sep 7. doi: 10.2174/1874609816666230816090934. Online ahead of print.

Authors

Inês Marques-Aleixo^{1

2}, Arnaldina Sampaio³, Lucimére Bohn^{1

2

3}, Flavia Machado³, Duarte Barros³, Oscár Ribeiro⁴, Joana Carvalho³, José Magalhães³

Affiliations

¹ Interdisciplinary Research Centre for Education and Development, Lusófona University, Lisbon, Portugal.
² Faculty of Psychology, Education and Sport, Lusófona University, Porto, Portugal.
³ Research Centre in Physical Activity, Health, and Leisure (CIAFEL), Laboratory for Integrative and Translational Research in Population Health (ITR), Faculty of Sport, University of Porto, Porto, Portugal.
⁴ CINTESIS - Center for Health Technology and Services Research, Department of Education and Psychology, University of Aveiro, Aveiro, Portugal.

PMID: 37904566
DOI: 10.2174/1874609816666230816090934

Abstract

Background: Neuropsychiatric symptoms (NPS) are highly prevalent among individuals with major neurocognitive disorders (MNCD).

Objective: Here, we characterized blood biomarkers (metabolic, inflammatory, neurotrophic profiles and total antioxidant), body composition, physical fitness and quality of life (QoL) in individuals with MNCD according to NPS.

Methods: The sample comprised 34 older adults (71.4% women; 74.06±6.03 yrs, with MNCD diagnosis) categorized according to 50th percentile [Low (≤12) or High (≥13)] for NPS (Neuropsychiatric Inventory Questionnaire). Sociodemographic, clinical data, body composition, anthropometric, cognitive assessment (ADAS-Cog), physical fitness (Senior Fitness Test), QoL (QoL-Alzheimer's Disease scale) were evaluated, and blood samples were collected for biochemical analysis.

Results: Low compared to high NPS group showed higher levels of IL-6, IGF-1and neurotrophic zscore (composite of IGF-1, VEGF-1, BDNF). Additionally, low compared to high NPS group have higher QoL, aerobic fitness and upper body and lower body strength.

Conclusion: The severity of NPS seems to be related to modified neurotrophic and inflammatory outcomes, lower physical fitness, and poor QoL. Strategies to counteract NPS development may preserve the physical and mental health of individuals with MNCD.

Keywords: Alzheimer disease; Blood biomarkers; Dementia; Neuropsychiatric Inventory Questionnaire; Seniors.