Early detection of chronic obstructive pulmonary disease in primary care: a randomised controlled trial

Br J Gen Pract. 2023 Nov 30;73(737):e876-e884. doi: 10.3399/BJGP.2022.0565. Print 2023 Dec.

Abstract

Background: Worldwide, chronic obstructive pulmonary disease (COPD) remains largely underdiagnosed.

Aim: To assess whether the use of Global Initiative for Chronic Obstructive Lung Disease (GOLD) questions and COPD coordination, either alone or combined, would detect new COPD cases in primary care.

Design and setting: GPs in Brittany, France, systematically enrolled patients aged 40-80 years over a 4-month period in this French multicentre cluster randomised controlled study.

Method: GPs were randomly allocated to one of four groups: control (standard of care), GOLD questions (adapted from symptoms and risk factors identified by GOLD), COPD coordination, and GOLD questions with COPD coordination. New cases of COPD were those confirmed by spirometry: post-bronchodilator forced expiratory volume in 1 second over forced vital capacity of <0.7.

Results: In total, 11 430 consultations were conducted by 47 GPs, who enrolled 3162 patients who did not have prior diagnosed asthma or COPD. Among these, 802 (25%) were enrolled in the control, 820 (26%) in the GOLD questions, 802 (25%) in the COPD coordination, and 738 (23%) in the GOLD questions with COPD coordination groups. In the control group, COPD was not evoked, and no spirometry was prescribed. All new cases of COPD diagnosed (n = 24, 0.8%) were in the intervention groups, representing 6.8% of patients who performed spirometry. Statistically significantly more new cases of COPD were detected with COPD coordination (P = 0.01).

Conclusion: Interventions that can be easily implemented, such as the GOLD questions and COPD coordination, can identify new cases of COPD. Studies are needed to identify the most appropriate case-finding strategies for GPs to detect COPD in primary care for each country.

Keywords: GOLD questions; chronic obstructive pulmonary disease; early detection; general practice; primary care.

Publication types

  • Randomized Controlled Trial
  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Asthma* / diagnosis
  • Forced Expiratory Volume
  • Humans
  • Middle Aged
  • Primary Health Care
  • Pulmonary Disease, Chronic Obstructive* / diagnosis
  • Spirometry
  • Vital Capacity