Impact of mood stabilizers on creativity

Australas Psychiatry. 2024 Feb;32(1):38-40. doi: 10.1177/10398562231211127. Epub 2023 Oct 30.

Abstract

Objective: While a DSM-5 criterion for both hypomania and mania is impaired functioning, the majority of those with a bipolar condition report improved functioning. When offered a mood stabilizer, many express concerns about any impact on their creativity. This piece seeks to address the question and attendant issues.

Method: Reference is made to the impact of differing mood stabilizers on cognitive performance and the limited data on any specific impact on creativity, while some personal observations are offered.

Results: There appears to be a distinctive gradient in the cognitive impacts of differing mood stabilizers, with lithium offering the highest risk, carbamazepine and valproate providing a slight risk, and lamotrigine seemingly without cognitive side-effects.

Conclusions: The question not only invites a nuanced response from the clinician but argues for close observation of any cognitive side-effects when lithium is introduced.

Keywords: bipolar disorder; cognitive side-effects; manic depressive illness; mood stabilizers.

MeSH terms

  • Anticonvulsants / therapeutic use
  • Antimanic Agents / therapeutic use
  • Antipsychotic Agents* / therapeutic use
  • Bipolar Disorder* / drug therapy
  • Humans
  • Lithium / therapeutic use
  • Mania

Substances

  • Lithium
  • Antimanic Agents
  • Anticonvulsants
  • Antipsychotic Agents