ATP-responsive Mn(II)-based T1 contrast agent for MRI

Sellamuthu Anbu; Lawerence Kenning; Graeme J Stasiuk

doi:10.1039/d3cc03430e

ATP-responsive Mn(II)-based T₁ contrast agent for MRI

Chem Commun (Camb). 2023 Nov 14;59(91):13623-13626. doi: 10.1039/d3cc03430e.

Authors

Sellamuthu Anbu^{1

2}, Lawerence Kenning³, Graeme J Stasiuk⁴

Affiliations

¹ Departments of Chemistry and Biomedical Sciences, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. bioinorg_anbu@yahoo.com.
² School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
³ MRI Centre, Royal Infirmary Hospital NHS Trust, Anlaby Road, Hull, HU3 2JZ, UK.
⁴ Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, Fourth Floor Lambeth Wing, St Thomas' Hospital, London, SE1 7EH, UK. graeme.stasiuk@kcl.ac.uk.

Abstract

A novel diacetylpyridylcarbohydrazide-DAPyCOHz-based manganese(II) chelate with dipicolylamine/zinc(II) (DPA/Zn²⁺) arms (MnLDPA-Zn2) was developed for adenosine triphosphate (ATP) responsive magnetic resonance imaging (MRI) T₁ contrast applications. Compound 2 shows enhanced relaxivity (r₁ = 11.52 mM^-1 s^-1) upon selective ATP binding over other phosphates.

MeSH terms

Contrast Media* / chemistry
Magnetic Resonance Imaging* / methods
Manganese / chemistry

Substances

Contrast Media
Manganese