Dendritic cells in liver transplantation immune response

Xiaodong Du; Mingqian Li; Chen Huan; Guoyue Lv

doi:10.3389/fcell.2023.1277743

Dendritic cells in liver transplantation immune response

Front Cell Dev Biol. 2023 Oct 13:11:1277743. doi: 10.3389/fcell.2023.1277743. eCollection 2023.

Authors

Xiaodong Du^#¹, Mingqian Li^#¹, Chen Huan², Guoyue Lv¹

Affiliations

¹ Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, China.
² Center of Infectious Diseases and Pathogen Biology, Institute of Virology and AIDS Research, Key Laboratory of Organ Regeneration and Transplantation of The Ministry of Education, The First Hospital of Jilin University, Changchun, China.

^# Contributed equally.

Abstract

Dendritic cells (DCs) are the most powerful antigen presenting cells (APCs), they are considered one of the key regulatory factors in the liver immune system. There is currently much interest in modulating DC function to improve transplant immune response. In liver transplantation, DCs participate in both the promotion and inhibition of the alloreponse by adopting different phenotypes and function. Thus, in this review, we discussed the origin, maturation, migration and pathological effects of several DC subsets, including the conventional DC (cDC), plasmacytoid DC (pDC) and monocyte-derived DC (Mo-DC) in liver transplantation, and we summarized the roles of these DC subsets in liver transplant rejection and tolerance. In addition, we also outlined the latest progress in DC-based related treatment regimens. Overall, our discussion provides a beneficial resource for better understanding the biology of DCs and their manipulation to improve the immune adaptability of patients in transplant status.

Keywords: DC based treatment; dendritic cells; immune rejection; immune tolerance; liver transplantation.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Financial support was provided by the National Natural Science Foundation of China (U20A20360 and 81901627), Science and Technology Department of Jilin Province (YDZJ202201ZYTS678).