The characteristics and molecular targets of antiarrhythmic natural products

Jun Yang; Kejun Ye; Rui Zhang; Xinrong Fan; Rui Xiong; Shiyu Zhang; Qiming Liu; Miao Lin; Bin Wang; Xiaoqiu Tan; Qiang Wen; Xianhong Ou

doi:10.1016/j.biopha.2023.115762

The characteristics and molecular targets of antiarrhythmic natural products

Biomed Pharmacother. 2023 Dec:168:115762. doi: 10.1016/j.biopha.2023.115762. Epub 2023 Oct 26.

Authors

Jun Yang¹, Kejun Ye², Rui Zhang³, Xinrong Fan⁴, Rui Xiong⁵, Shiyu Zhang³, Qiming Liu⁶, Miao Lin³, Bin Wang⁴, Xiaoqiu Tan⁷, Qiang Wen⁸, Xianhong Ou⁹

Affiliations

¹ Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China; Department of Pharmacy, Santai County People's Hospital of Sichuan Province, Mianyang 621100, China.
² Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China; Pharmacy Department, Chongqing Armed Police Corps Hospital, Chongqing 400061, China.
³ Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.
⁴ The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
⁵ Department of Pharmacy of the 958 Hospital of Chinese PLA/Jiangbei Campus, The First Affiliated Hospital of Army Medical University, Chongqing 400020, China.
⁶ School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.
⁷ Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China; School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China. Electronic address: tanxiaoqiu@swmu.edu.cn.
⁸ Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: wenqiang@hust.edu.cn.
⁹ Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, Guangxi Province, China. Electronic address: oxh8081@swmu.edu.cn.

PMID: 37897974
DOI: 10.1016/j.biopha.2023.115762

Abstract

Arrhythmia is one of the most common cardiovascular diseases. The search for new drugs to suppress various types of cardiac arrhythmias has always been the focus of attention. In the past decade, the screening of antiarrhythmic active substances from plants has received extensive attention. These natural compounds have obvious antiarrhythmic effects, and chemical modifications based on natural compounds have greatly increased their pharmacological properties. The chemical modification of botanical antiarrhythmic drugs is closely related to the development of new and promising drugs. Therefore, the structural characteristics and action targets of natural compounds with antiarrhythmic effects are reviewed in this paper, so that pharmacologists can select antiarrhythmic lead compounds from natural compounds based on the disease target - chemical structural characteristics.

Keywords: Action characteristics; Antiarrhythmic; Cardioprotection; Natural product; Review; Target.

Publication types

Review

MeSH terms

Anti-Arrhythmia Agents* / pharmacology
Anti-Arrhythmia Agents* / therapeutic use
Arrhythmias, Cardiac / drug therapy
Biological Products* / pharmacology
Biological Products* / therapeutic use
Humans

Substances

Anti-Arrhythmia Agents
Biological Products