Synthesis of Fused-Ring Derivatives Containing Bifluorenylidene Units via Pd-Catalyzed Tandem Multistep Suzuki Coupling/Heck Cyclization Reaction

J Org Chem. 2023 Nov 17;88(22):15964-15968. doi: 10.1021/acs.joc.3c01140. Epub 2023 Oct 28.

Abstract

A series of bifluorenylidene derivatives has been facilely synthesized via a palladium-catalyzed tandem multistep Suzuki cross-coupling and Heck cyclization in one pot. The tandem reaction involves two sequential Suzuki couplings and a subsequent Heck cyclization. The target products are obtained in good yields up to 94%. Even in an extended conjugated substrate, the anticipated products can be prepared.