SARS-CoV-2 and Brain Health: New Challenges in the Era of the Pandemic

Waqas Ahmed; Jia Feng; Yifan Zhang; Lukui Chen

doi:10.3390/microorganisms11102511

SARS-CoV-2 and Brain Health: New Challenges in the Era of the Pandemic

Microorganisms. 2023 Oct 8;11(10):2511. doi: 10.3390/microorganisms11102511.

Authors

Waqas Ahmed^{1

2}, Jia Feng^{1

3}, Yifan Zhang¹, Lukui Chen¹

Affiliations

¹ Department of Neurosurgery, Neuroscience Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510310, China.
² School of Medicine, Southeast University, Nanjing 210009, China.
³ Guangdong Second Provincial General Hospital, Guangzhou 510317, China.

Abstract

Respiratory viral infections have been found to have a negative impact on neurological functions, potentially leading to significant neurological impairment. The SARS-CoV-2 virus has precipitated a worldwide pandemic, posing a substantial threat to human lives. Growing evidence suggests that SARS-CoV-2 may severely affect the CNS and respiratory system. The current prevalence of clinical neurological issues associated with SARS-CoV-2 has raised significant concerns. However, there needs to be a more comprehensive understanding of the specific pathways by which SARS-CoV-2 enters the nervous system. Based on the available evidence, this review focuses on the clinical neurological manifestations of SARS-CoV-2 and the possible mechanisms by which SARS-CoV-2 invades the brain.

Keywords: BBB; CNS; COVID-19; SARS-CoV-2; transmission routes.

Publication types

Review

Abstract

Publication types

Grants and funding