Research Progress on the Structural and Functional Roles of hnRNPs in Muscle Development

Zhenyang Li; Haimei Wei; Debao Hu; Xin Li; Yiwen Guo; Xiangbin Ding; Hong Guo; Linlin Zhang

doi:10.3390/biom13101434

Research Progress on the Structural and Functional Roles of hnRNPs in Muscle Development

Biomolecules. 2023 Sep 22;13(10):1434. doi: 10.3390/biom13101434.

Authors

Zhenyang Li¹, Haimei Wei¹, Debao Hu¹, Xin Li¹, Yiwen Guo¹, Xiangbin Ding¹, Hong Guo¹, Linlin Zhang¹

Affiliation

¹ Key Laboratory of Animal Breeding and Healthy Livestock Farming, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, China.

Abstract

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a superfamily of RNA-binding proteins consisting of more than 20 members. These proteins play a crucial role in various biological processes by regulating RNA splicing, transcription, and translation through their binding to RNA. In the context of muscle development and regeneration, hnRNPs are involved in a wide range of regulatory mechanisms, including alternative splicing, transcription regulation, miRNA regulation, and mRNA stability regulation. Recent studies have also suggested a potential association between hnRNPs and muscle-related diseases. In this report, we provide an overview of our current understanding of how hnRNPs regulate RNA metabolism and emphasize the significance of the key members of the hnRNP family in muscle development. Furthermore, we explore the relationship between the hnRNP family and muscle-related diseases.

Keywords: alternative splicing; hnRNPs; muscle development; muscle disorders.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Heterogeneous-Nuclear Ribonucleoproteins* / genetics
Heterogeneous-Nuclear Ribonucleoproteins* / metabolism
MicroRNAs* / genetics
MicroRNAs* / metabolism
Muscle Development / genetics
RNA Splicing
RNA-Binding Proteins / metabolism

Substances

Heterogeneous-Nuclear Ribonucleoproteins
RNA-Binding Proteins
MicroRNAs

Grants and funding

This research study was funded by the National Natural Science Foundation of China (grant number 31902151) the Scientific Research Program of Tianjin Education Commission (grant number 2021KJ107 and 2020KJ089). Tianjin Agricultural University scientific research innovation project (2021XY039).