Association between depressive and anxious symptoms with cognitive function and quality of life in drug-resistant epilepsy

E Monteagudo-Gimeno; R Sánchez-González; J Raduà-Castaño; L Fortea-González; T Boget-Llucià; M Carreño-Martínez; A Donaire-Pedraza; N Bargalló-Alabart; X Setoain-Perego; J Rumià-Arboix; A Bulbena-Vilarrasa; L Pintor-Pérez

doi:10.1016/j.heliyon.2023.e20903

Association between depressive and anxious symptoms with cognitive function and quality of life in drug-resistant epilepsy

Heliyon. 2023 Oct 14;9(10):e20903. doi: 10.1016/j.heliyon.2023.e20903. eCollection 2023 Oct.

Authors

E Monteagudo-Gimeno^{1

2}, R Sánchez-González^{3

4}, J Raduà-Castaño^{5

6

7

8

9}, L Fortea-González^{5

7

10}, T Boget-Llucià^{5

10

11}, M Carreño-Martínez^{5

10

11}, A Donaire-Pedraza^{5

10

11}, N Bargalló-Alabart^{5

11}, X Setoain-Perego^{5

10

11

12}, J Rumià-Arboix^{10

11}, A Bulbena-Vilarrasa^{1

3}, L Pintor-Pérez^{5

10

13}

Affiliations

¹ Department of Psychiatry and Forensic Medicine, School of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Spain.
² Benito Menni Mental Health Care Complex, Sant Boi de Llobregat, Barcelona, Spain.
³ Department of Psychiatry, Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Barcelona, Spain.
⁴ IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
⁵ Biomedical Research Institute August Pi i Sunyer (IDIBAPS), Hospital Clinic of Barcelona, Barcelona, Spain.
⁶ FIDMAG Research Foundation, Sant Boi de Llobregat, Barcelona, Spain.
⁷ Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
⁸ Centre for Psychiatric Research and Education, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
⁹ Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
¹⁰ Clinical Institute of Neurosciences, Hospital Clinic of Barcelona, Barcelona, Spain.
¹¹ Epilepsy Unit, Neurology Department, Hospital Clinic of Barcelona, Barcelona, Spain.
¹² Biomedical Imaging Group, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain.
¹³ Consultation-Liaison Service, Department of Psychiatry, Institut de Neurociències, Universitat de Barcelona, Hospital Clínic i Provincial de Barcelona, Barcelona, Spain.

Abstract

•Depressive/anxious disorders and cognitive impairment are frequent comorbidities in epilepsy and have a more deleterious effect in DRE.•Studies concerning the relationship between anxiety and depression and cognitive performance in DRE are scarce.•Higher scores in HADS are associated with lower QOLIE-31 scores and might be considered as predictors of QOL in DRE.•A relationship between anxious and depressive symptoms -measured with HADS and SCL-90R- and cognition might not exist.•There remains an unexplored study area regarding this relationship which requires more attention to improve the assessment of DRE.