Simian Varicella Virus Infection and Reactivation in Rhesus Macaques Trigger Cytokine and Aβ40/42 Alterations in Serum and Cerebrospinal Fluid

Christy S Niemeyer; Vicki Traina-Dorge; Lara Doyle-Meyers; Arpita Das; Jayme Looper; Teresa Mescher; Brittany Feia; Eva Medina; Maria A Nagel; Ravi Mahalingam; Andrew N Bubak

doi:10.21203/rs.3.rs-3367215/v1

Simian Varicella Virus Infection and Reactivation in Rhesus Macaques Trigger Cytokine and Aβ40/42 Alterations in Serum and Cerebrospinal Fluid

Res Sq [Preprint]. 2023 Oct 16:rs.3.rs-3367215. doi: 10.21203/rs.3.rs-3367215/v1.

Authors

Affiliations

¹ University of Colorado Anschutz Medical Campus School of Medicine.
² Tulane National Primate Research Center.
³ Louisiana State University School of Veterinary Medicine.
⁴ University of Colorado School of Medicine: University of Colorado Anschutz Medical Campus School of Medicine.

Abstract

Simian varicella virus (SVV) produces peripheral inflammatory responses during varicella (primary infection) and zoster (reactivation) in rhesus macaques (RM). However, it is unclear if peripheral measures are accurate proxies for central nervous system (CNS) responses. Thus, we analyzed cytokine and Aβ42/Aβ40 changes in paired serum and cerebrospinal fluid (CSF) during the course of infection. During varicella and zoster, every RM had variable changes in serum and CSF cytokine and Aβ42/Aβ40 levels compared to pre-inoculation levels. Overall, peripheral infection appears to affect CNS cytokine and Aβ42/Aβ40 levels independent of serum responses, suggesting that peripheral disease may contribute to CNS disease.

Keywords: Amyloid-beta; Cytokine; Simian Varicella Virus; Varicella; Zoster.

Publication types

Preprint

Abstract

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