Preliminary Consequences of Blood Pressure Management and Blood Homocysteine Levels with Perindopril in Newly Diagnosed Hypertensive Patients in the Vietnamese Population

Son Kim Tran; An Bao Truong; Phi Hoang Nguyen; Toan Hoang Ngo; Tuyen Long Vu; Khoa Dang Dang Tran; Phuong Minh Vo; Bao The Nguyen; Tuong Le Trong Huynh; Kien Trung Nguyen; Hung Do Tran

doi:10.1155/2023/1933783

Preliminary Consequences of Blood Pressure Management and Blood Homocysteine Levels with Perindopril in Newly Diagnosed Hypertensive Patients in the Vietnamese Population

Int J Hypertens. 2023 Oct 18:2023:1933783. doi: 10.1155/2023/1933783. eCollection 2023.

Affiliations

¹ Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho 900000, Vietnam.
² Department of Cardiology, An Giang Cardiovascular Hospital, Long Xuyen 880000, Vietnam.
³ Department of Foreign Language, Can Tho University, Can Tho 90000, Vietnam.
⁴ Department of Cardiology, Can Tho Central General Hospital, Can Tho 90000, Vietnam.
⁵ Faculty of Nursing and Medical Technology, Can Tho University of Medicine and Pharmacy, Can Tho 900000, Vietnam.

Abstract

Background: Perindopril is an ACE inhibitor that aids in both blood pressure regulation and homocysteine reduction.

Objectives: Our study aimed to evaluate the results of controlling blood pressure and blood homocysteine levels by perindopril in patients with primary hypertension.

Materials and methods: A cross-sectional descriptive study with a longitudinal follow-up was conducted on 105 primary hypertensive patients treated with perindopril.

Results: The results of our study showed that after 6 weeks of treatment with perindopril, the proportion of patients with the target blood pressure (BP) level accounted for 70.5%, the rate of grade 1 hypertension decreased from 61.0% to 25.7%, grade 2 blood pressure decreased from 17.1% to 3.8%, and there was no case of grade 3 hypertension. At the same time, we also found that the rate of BP control in the group of patients who controlled Hcy below a threshold of 15 μmol/L was significantly higher than in the other group (p < 0.05). Concerning the efficacy of decreasing homocysteine in blood, we discovered that after 6 weeks of treatment with perindopril, the proportion of patients with elevated homocysteine reduced considerably from 74.3% to 40% (p < 0.05). In addition, the homocysteine concentration was 4.33 mol/L lower after treatment than before treatment (95% CI: 3.69-4.97) (p < 0.05).

Conclusion: Perindopril helps control blood pressure and reduces blood homocysteine levels in patients with primary hypertension.