Role of T cells in cervical cancer

Issam Alshami; Raghad O Alattas; Alofi Waad A; Sayed Anwar A

doi:10.6026/97320630019556

Role of T cells in cervical cancer

Bioinformation. 2023 May 31;19(5):556-561. doi: 10.6026/97320630019556. eCollection 2023.

Authors

Issam Alshami^{1

2}, Raghad O Alattas^{1

2}, Alofi Waad A^{1

2}, Sayed Anwar A^{1

2}

Affiliations

¹ Department of Medical Microbiology and Immunology, Taibah University, Madinah, Saudi Arabia.
² College of Medicine, Taibah University, Madinah, Saudi Arabia.

Abstract

Cervical cancer is an important health problem and it is considered the fourth most lethal women's cancer worldwide. The intertumoral T cell pool is exposed in a number of immunosuppressive pathways. Therefore, it is of interest to document the effect of cervical cancer on immune system, the role of T cells in the development and pathogenesis of cervical cancer. HPV is considered the most important risk factors for developing cervical cancer, HPV 16 and 18, the two most common oncogenic types which are high risk HPV cause 70% of cervical cancer cases. In the cervical mucosa, the proportion of CD4+ and CD8+ T cells is related to the severity of the lesions. Cervical cancer can be treated by immunotherapeutic vaccine which involves T cells. T cells play an important part in cervical cancer pathogenesis because HPV exploits several methods to avoid host T-cell immune surveillance. T-cell-based immunotherapy is important because it is selective and has therapeutic potential.

Keywords: Cervical cancer; Human papillomavirus; T cells.

Publication types

Review