Polydopamine-curcumin coating of titanium for remarkable antibacterial activity via synergistic photodynamic and photothermal properties

Qing Guo; Peiyuan Li; Ying Zhang; Hongjun Yan; Qiuyan Yan; Rixiang Su; Wei Su

doi:10.1111/php.13870

Polydopamine-curcumin coating of titanium for remarkable antibacterial activity via synergistic photodynamic and photothermal properties

Photochem Photobiol. 2023 Oct 26. doi: 10.1111/php.13870. Online ahead of print.

Authors

Qing Guo¹, Peiyuan Li¹, Ying Zhang¹, Hongjun Yan¹, Qiuyan Yan¹, Rixiang Su¹, Wei Su²

Affiliations

¹ College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China.
² Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning, China.

PMID: 37882412
DOI: 10.1111/php.13870

Abstract

Combined photothermal therapy (PTT) and photodynamic therapy (PDT) has emerged as a novel and effective antibacterial strategy. In order to endow titanium (Ti) with antibacterial properties, the Ti-PDA-Cur composite was prepared using the excellent adhesion properties of polydopamine (PDA) to load curcumin (Cur) on the surface of Ti. The Ti-PDA-Cur coating can produce singlet oxygen (¹ O₂ ) and heat under 405 + 808 nm light irradiation, which can effectively kill Staphylococcus aureus and Escherichia coli. Moreover, the cytotoxicity and hemolysis rate of Ti-PDA-Cur were low, indicating its good biocompatibility. Therefore, this study provided a new strategy for the development of new Ti implants.

Keywords: antibacteria; curcumin; photodynamic therapy; photothermal therapy; polydopamine; titanium.

Abstract

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