Hematologic Abnormalities After COVID-19 Infection: A Case of Coombs-Negative Hemolytic Anemia and Thrombocytopenia

Alanna Glidden Siegenthaler; Ghanshyam Ghelani; Amy Brady; Taylor Loon; Bhaskara Reddy Madhira

doi:10.1177/23247096231207687

Hematologic Abnormalities After COVID-19 Infection: A Case of Coombs-Negative Hemolytic Anemia and Thrombocytopenia

J Investig Med High Impact Case Rep. 2023 Jan-Dec:11:23247096231207687. doi: 10.1177/23247096231207687.

Authors

Alanna Glidden Siegenthaler¹, Ghanshyam Ghelani¹, Amy Brady¹, Taylor Loon¹, Bhaskara Reddy Madhira¹

Affiliation

¹ State University of New York Upstate Medical University, Syracuse, USA.

Abstract

The occurrence of hemolytic anemia in patients with active SARS-CoV-2 infection has been documented in medical literature. While relatively uncommon, there have been instances where this condition presents as a Coombs-negative hemolytic anemia. In this research study, we report a distinctive case of Coombs-negative hemolytic anemia and thrombocytopenia in a patient with a known history of COVID-19 infection. The patient demonstrated a favorable response to treatment involving the administration of steroids and intravenous immunoglobulin (IVIG) therapy. This case adds to the existing body of evidence regarding the hematological manifestations of SARS-CoV-2 infection, highlighting the importance of considering and managing hematological complications in patients with COVID-19.

Keywords: COVID-19; hemolytic anemia; thrombocytopenia.

Publication types

Case Reports

MeSH terms

Anemia, Hemolytic* / complications
Anemia, Hemolytic, Autoimmune* / complications
COVID-19* / complications
Coombs Test
Humans
Immunoglobulins, Intravenous / therapeutic use
SARS-CoV-2
Thrombocytopenia* / complications

Substances

Immunoglobulins, Intravenous