In this Perspective, we present the recent advances in atomic friction measured of two-dimensional materials obtained by friction force microscopy. Starting with the atomic-scale stick-slip behavior, a beautiful highly nonequilibrium process, we discuss the main factors that contribute to determine sliding friction between single asperity and a two-dimensional sheet including chemical identity of material, thickness, external load, sliding direction, velocity/temperature, and contact size. In particular, we focus on the latest progress of the more complex friction behavior of moiré systems involving 2D layered materials. The underlying mechanisms of these frictional characteristics observed during the sliding process by theoretical and computational studies are also discussed. Finally, a discussion and outlook on the perspective of this field are provided.