The amniotic membrane is a single epithelial layer of the placenta. It has anti-inflammatory, anti-scarring, anti-angiogenic and possibly bactericidal properties. The basement membrane of the amniotic membrane acts as a substrate to encourage healing and re-epithelialisation. It has been used in many ocular surface diseases including persistent epithelial defects (corneal or conjunctival), chemical or thermal burns, limbal stem cell deficiency, cicatrising conjunctivitis, ocular graft versus host disease, microbial keratitis, corneal perforation, bullous keratopathy, dry eye disease, corneal haze following refractive surgery and cross-linking, band keratopathy, ocular surface neoplasia, pterygium surgery, and ligneous conjunctivitis. This review provides an up-to-date overview of amniotic membrane transplantation including the structural and biological properties, preparation and application, clinical indications, and commercially available products.
摘要: 羊膜是胎盘的一层单一上皮组织。它具有抗炎、抗瘢痕、抗血管生成和抗菌特性。羊膜的基底膜作为基质, 具有促进愈合和重新上皮化的作用。它用于许多眼表疾病, 包括持续性上皮缺陷(角膜或结膜) 、化学或热烧伤、角膜缘干细胞缺乏、瘢痕性结膜炎、眼部移植物抗宿主疾病、微生物性角膜炎、角膜穿孔、大泡性角膜病变、干眼综合征、屈光矫视和交联术后的角膜混浊、带状角膜病变、眼表肿瘤、翼状胬肉手术和木样结膜炎。本综述提供了羊膜移植的最新概述, 包括结构和生物特性、制备和应用、临床适应症和商用产品。.
© 2023. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.