Two new alkaloids from the endophytic fungus Aspergillus fumigatus SAS10 isolated from the mangrove tree Sonneratia apetala

Zanhong Chen; Haisheng Liu; Bo Ding; Siyu Guo; Hongbo Huang; Yiwen Tao

doi:10.1080/14786419.2023.2272289

Two new alkaloids from the endophytic fungus Aspergillus fumigatus SAS10 isolated from the mangrove tree Sonneratia apetala

Nat Prod Res. 2023 Oct 24:1-6. doi: 10.1080/14786419.2023.2272289. Online ahead of print.

Authors

Zanhong Chen¹, Haisheng Liu¹, Bo Ding¹, Siyu Guo¹, Hongbo Huang¹, Yiwen Tao¹

Affiliation

¹ School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, Guangzhou, China.

PMID: 37874626
DOI: 10.1080/14786419.2023.2272289

Abstract

Two new alkaloids designated aspernigrin E (1) and pyranonigrin L (2) were isolated from mangrove endophytic fungus Aspergillus fumigatus SAS10, together with the known alkaloid compounds pyranonigrin A (3), asperazine (4), (+)-iso-pestalazine A (5), pestalazine A (6), and pestalazine B (7). The planar structures of the new compounds were elucidated by HR-MS and NMR spectroscopic data analyses. The absolute configurations of compounds 1 and 2 were determined by comparison of the electronic circular dichroic (ECD) spectra with the calculated ECD spectra. All these compounds were tested for anti-bacterial activity.

Keywords: Alkaloid; Aspergillus fumigatus; fungus; mangrove; secondary metabolite.