Concomitant Resistance to Cefiderocol and Ceftazidime/Avibactam in Two Carbapenemase-Producing Klebsiella pneumoniae Isolates from Two Lung Transplant Patients

Greta Bellinzona; Cristina Merla; Marta Corbella; Elizabeth Nagy Iskandar; Elena Seminari; Angela Di Matteo; Stefano Gaiarsa; Greta Petazzoni; Davide Sassera; Fausto Baldanti; Aurora Piazza; Patrizia Cambieri

doi:10.1089/mdr.2023.0054

Concomitant Resistance to Cefiderocol and Ceftazidime/Avibactam in Two Carbapenemase-Producing Klebsiella pneumoniae Isolates from Two Lung Transplant Patients

Microb Drug Resist. 2024 Jan;30(1):21-26. doi: 10.1089/mdr.2023.0054. Epub 2023 Oct 23.

Authors

Affiliations

¹ Department of Biology and Biotechnology, and Paediatric Sciences, University of Pavia, Pavia, Italy.
² Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
³ Specialization School of Microbiology and Virology, Microbiology and Virology Department, University of Pavia, Pavia, Italy.
⁴ Division of Infectious Diseases I, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
⁵ Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
⁶ Department of Clinical, Surgical, Diagnostic, and Paediatric Sciences, University of Pavia, Pavia, Italy.

PMID: 37870558
DOI: 10.1089/mdr.2023.0054

Abstract

In this study, we present two cases of Klebsiella pneumoniae, one KPC-33- and one NDM-1-producing, showing resistance to cefiderocol and ceftazidime/avibactam, collected in the intensive care unit of a hospital in Northern Italy from two patients who had recently undergone lung transplantation. Whole-genome sequencing was performed to investigate the molecular features of these strains.

Keywords: KPC mutated; Klebsiella pneumoniae; blaKPC-33; blaNDM-1; cefiderocol; cefiderocol resistance; ceftazidime/avibactam; ceftazidime/avibactam resistance; co-resistance; virulence factors.

MeSH terms

Anti-Bacterial Agents / pharmacology
Azabicyclo Compounds / pharmacology
Azabicyclo Compounds / therapeutic use
Bacterial Proteins / genetics
Carbapenem-Resistant Enterobacteriaceae*
Cefiderocol
Ceftazidime / pharmacology
Ceftazidime / therapeutic use
Drug Combinations
Humans
Klebsiella Infections* / drug therapy
Klebsiella pneumoniae / genetics
Microbial Sensitivity Tests
beta-Lactamases / genetics

Substances

Ceftazidime
carbapenemase
Anti-Bacterial Agents
Cefiderocol
avibactam
beta-Lactamases
Bacterial Proteins
Azabicyclo Compounds
Drug Combinations