Ciliary dyskinesia in severe asthma is not affected by chronic mucus hypersecretion

Céline Kempeneers; Romane Bonhiver; Noëmie Bricmont; Maud Pirotte; Sara Engelskirchen; Lionel Benchimol; Doriane Calmes; Françoise Guissard; Catherine Moermans; Marie-Christine Seghaye; Renaud Louis; Florence Schleich

doi:10.1183/23120541.00220-2023

Ciliary dyskinesia in severe asthma is not affected by chronic mucus hypersecretion

ERJ Open Res. 2023 Oct 2;9(5):00220-2023. doi: 10.1183/23120541.00220-2023. eCollection 2023 Sep.

Authors

Céline Kempeneers^{1

2}, Romane Bonhiver^{1

2}, Noëmie Bricmont^{1

2}, Maud Pirotte¹, Sara Engelskirchen^{1

2}, Lionel Benchimol³, Doriane Calmes⁴, Françoise Guissard⁴, Catherine Moermans^{2

4}, Marie-Christine Seghaye^{2

5}, Renaud Louis^{2

4}, Florence Schleich^{2

4}

Affiliations

¹ Division of Respirology, Department of Pediatrics, University Hospital Liège, Liège, Belgium.
² Pneumology laboratory, I3 Group, GIGA Research Center, University of Liège, Liège, Belgium.
³ Department of ENT, University Hospital Liège, Liège, Belgium.
⁴ Department of Pneumology, University Hospital Liège, Liège, Belgium.
⁵ Division of Cardiology, Department of Pediatrics, University Hospital Liège and University of Liège, Liège, Belgium.

Abstract

Chronic mucus hypersecretion (CMH) is linked to increased asthma severity. Ciliary dyskinesia is present in severe asthma but CMH was not associated with a worse ciliary dysfunction, suggesting another mechanism to explain chronic cough and phlegm. https://bit.ly/3JNUgGr.