The role of TRIM family in metabolic associated fatty liver disease

Front Endocrinol (Lausanne). 2023 Oct 5:14:1210330. doi: 10.3389/fendo.2023.1210330. eCollection 2023.

Abstract

Metabolic associated fatty liver disease (MAFLD) ranks among the most prevalent chronic liver conditions globally. At present, the mechanism of MAFLD has not been fully elucidated. Tripartite motif (TRIM) protein is a kind of protein with E3 ubiquitin ligase activity, which participates in highly diversified cell activities and processes. It not only plays an important role in innate immunity, but also participates in liver steatosis, insulin resistance and other processes. In this review, we focused on the role of TRIM family in metabolic associated fatty liver disease. We also introduced the structure and functions of TRIM proteins. We summarized the TRIM family's regulation involved in the occurrence and development of metabolic associated fatty liver disease, as well as insulin resistance. We deeply discussed the potential of TRIM proteins as targets for the treatment of metabolic associated fatty liver disease.

Keywords: TRIM family; insulin resistance; metabolic associated fatty liver disease; metabolism; ubiquitination.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Insulin Resistance*
  • Proteins / metabolism
  • Tripartite Motif Proteins / chemistry
  • Tripartite Motif Proteins / genetics
  • Tripartite Motif Proteins / metabolism
  • Ubiquitin-Protein Ligases* / genetics
  • Ubiquitination

Substances

  • Ubiquitin-Protein Ligases
  • Proteins
  • Tripartite Motif Proteins

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (Grant No. 82270650), the Natural Science Foundation of Jilin Province, China (Grant No. 20210101003JC) and Graduate Innovation Fund of Jilin University.