Human monkeypox: An updated appraisal on epidemiology, evolution, pathogenesis, clinical manifestations, and treatment strategies

Mohammad Ejaz; Momina Jabeen; Mehmoona Sharif; Muhammad Ali Syed; Pir T Shah; Rani Faryal

doi:10.1002/jobm.202300455

Human monkeypox: An updated appraisal on epidemiology, evolution, pathogenesis, clinical manifestations, and treatment strategies

J Basic Microbiol. 2024 Feb;64(2):e2300455. doi: 10.1002/jobm.202300455. Epub 2023 Oct 22.

Authors

Mohammad Ejaz^{1

2}, Momina Jabeen³, Mehmoona Sharif², Muhammad Ali Syed⁴, Pir T Shah⁵, Rani Faryal²

Affiliations

¹ Department of Microbiology, Government Postgraduate College Mandian, Abbottabad, Pakistan.
² Department of Microbiology, Quaid-i-Azam University, Islamabad, Pakistan.
³ National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.
⁴ Department of Microbiology, The University of Haripur, Haripur, Pakistan.
⁵ Institute of Biomedical Sciences, Shanxi University, Taiyuan, Shanxi, China.

PMID: 37867205
DOI: 10.1002/jobm.202300455

Abstract

Monkeypox (Mpox) is a zoonotic viral disease caused by the monkeypox virus (MPXV), a member of the Orthopoxvirus genus. The recent occurrence of Mpox infections has become a significant global issue in recent months. Despite being an old disease with a low mortality rate, the ongoing multicountry outbreak is atypical due to its occurrence in nonendemic countries. The current review encompasses a comprehensive analysis of the literature pertaining to MPXV, with the aim of consolidating the existing data on the virus's epidemiological, biological, and clinical characteristics, as well as vaccination and treatment regimens against the virus.

Keywords: Orthopoxvirus; clinical manifestations; global health; monkeypox; zoonosis.

Publication types

Review

MeSH terms

Disease Outbreaks
Humans
Mpox (monkeypox)* / epidemiology
Mpox (monkeypox)* / prevention & control
Vaccination