Neonatal Blood Banking Practices

Elizabeth P Crowe; Ruchika Goel; Nour Al-Mozain; Cassandra D Josephson

doi:10.1016/j.clp.2023.07.008

Neonatal Blood Banking Practices

Clin Perinatol. 2023 Dec;50(4):821-837. doi: 10.1016/j.clp.2023.07.008. Epub 2023 Sep 20.

Authors

Elizabeth P Crowe¹, Ruchika Goel², Nour Al-Mozain³, Cassandra D Josephson⁴

Affiliations

¹ Department of Pathology, Johns Hopkins University School of Medicine, 1800 Orleans Street, Sheikh Zayed Tower, Room 3081-A, Baltimore, MD 21287, USA.
² Corporate Medical Affairs, Vitalant National Office, Scottsdale, AZ, USA; Division of Hematology/Oncology, Department of Internal Medicine and Pediatrics, Simmons Cancer Institute at SIU School of Medicine, 704 Lismore Lane, Springfield, IL 62704, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
³ Hematopathology & Transfusion Medicine, Department of Pathology & Laboratory Medicine, King Faisal Specialist Hospital & Research Centre, 7652, Riyadh, Riyadh, 12713, Saudi Arabia; Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
⁴ Department of Oncology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Cancer and Blood Disorders Institute, Blood Bank and Transfusion Medicine, Department of Pathology, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. Electronic address: cjosep22@jhmi.edu.

PMID: 37866850
DOI: 10.1016/j.clp.2023.07.008

Abstract

There is little formal guidance to direct neonatal blood banking practices and, as a result, practices vary widely across institutions. In this vulnerable patient population with a high transfusion burden, considerations for blood product selection include freshness, extended-storage media, pathogen inactivation, and other modifications. The authors discuss the potential unintended adverse impacts in the neonatal recipient. Concerns such as immunodeficiency, donor exposures, cytomegalovirus transmission, volume overload, transfusion-associated hyperkalemia, and passive hemolysis from ABO incompatibility have driven modifications of blood components to improve safety.

Keywords: Neonate; Platelets; Premature; Red blood cells; Transfusion.

Publication types

Review

MeSH terms

ABO Blood-Group System*
Blood Banking*
Blood Group Incompatibility
Blood Transfusion
Hemolysis
Humans
Infant, Newborn

Substances

ABO Blood-Group System