MicroRNA regulators of vascular pathophysiology in chronic kidney disease

Kun-Lin Wu; Chien-Lung Chen; Mai-Huong Thi Nguyen; Jen-Chieh Tsai; Sun-Chong Wang; Wen-Fang Chiang; Po-Jen Hsiao; Jenq-Shyong Chan; Ju Jung Hou; Nianhan Ma

doi:10.1016/j.cca.2023.117610

MicroRNA regulators of vascular pathophysiology in chronic kidney disease

Clin Chim Acta. 2023 Nov 1:551:117610. doi: 10.1016/j.cca.2023.117610. Epub 2023 Oct 18.

Authors

Affiliations

¹ Department of Biomedical Sciences and Engineering, Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan, Taiwan; Division of Nephrology, Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan; Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
² Division of Nephrology, Department of Medicine, Landseed International Hospital, Taoyuan, Taiwan.
³ Department of Biomedical Sciences and Engineering, Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan, Taiwan.
⁴ Department of Biomedical Sciences and Engineering, Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan, Taiwan; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
⁵ Division of Nephrology, Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan; Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
⁶ Kaohsiung Medical University Hospital, Department of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁷ Department of Biomedical Sciences and Engineering, Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan, Taiwan. Electronic address: nianhan.ma@g.ncu.edu.tw.

PMID: 37863246
DOI: 10.1016/j.cca.2023.117610

Abstract

Coronary artery disease (CAD) is a severe comorbidity in chronic kidney disease (CKD) due to heavy calcification in the medial layer and inflamed plaques. Chronic inflammation, endothelial dysfunction and vascular calcification are major contributors that lead to artherosclerosis in CKD. The lack of specific symptoms and signs of CAD and decreased accuracy of noninvasive diagnostic tools result in delayed diagnosis leading to increased mortality. MicroRNAs (miRNAs) are post-transcriptional regulators present in various biofluids throughout the body. In the circulation, miRNAs have been reported to be encapsulated in extracellular vesicles and serve as stable messengers for crosstalk among cells. miRNAs are involved in pathophysiologic mechanisms including CAD and can potentially be extended from basic research to clinical translational practice.

Keywords: Chronic kidney disease; Coronary artery disease; MicroRNA.

Publication types

Review

MeSH terms

Coronary Artery Disease* / diagnosis
Humans
MicroRNAs* / genetics
Plaque, Atherosclerotic*
Renal Insufficiency, Chronic* / genetics
Vascular Calcification* / genetics

Substances

MicroRNAs