Polydopamine functionalized polyurethane shape memory sponge with controllable expansion performance triggered by near-infrared light for incompressible hemorrhage control

Feng Sang; Luqi Pan; Zhixiao Ji; Bingxu Zhang; Zhizhen Meng; Lina Cao; Jing Zhang; Xujian Li; Xiao Yang; Changcan Shi

doi:10.1016/j.colsurfb.2023.113590

Polydopamine functionalized polyurethane shape memory sponge with controllable expansion performance triggered by near-infrared light for incompressible hemorrhage control

Colloids Surf B Biointerfaces. 2023 Dec:232:113590. doi: 10.1016/j.colsurfb.2023.113590. Epub 2023 Oct 13.

Authors

Feng Sang¹, Luqi Pan², Zhixiao Ji², Bingxu Zhang¹, Zhizhen Meng³, Lina Cao¹, Jing Zhang⁴, Xujian Li⁵, Xiao Yang⁶, Changcan Shi⁷

Affiliations

¹ School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China.
² Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China.
³ Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
⁴ College of Materials Science and Engineering, Donghua University, Shanghai 200051, China.
⁵ Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China. Electronic address: lixj@wiucas.ac.cn.
⁶ Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China. Electronic address: yangxiao@ucas.ac.cn.
⁷ School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address: shicc@ucas.ac.cn.

PMID: 37862950
DOI: 10.1016/j.colsurfb.2023.113590

Abstract

Uncontrolled expansion of shape memory sponges face a significant challenge in the treatment of lethal incompressible hemorrhage, which can lead to blood overflow or damage to the surrounding tissue. Herein, we developed a polydopamine functionalized polyurethane shape memory sponge (PDA-TPI-PU) with a controllable degree of expansion by near-infrared (NIR) light-triggered stimulation for the treatment of incompressible hemorrhage. The sponge has excellent liquid absorption performance and robust mechanical strength as well as good photothermal conversion ability. Under NIR light of 0.32 W/cm², the maximum recovery rate of the fixed-shape compression sponge was 91% within 25 s in air and 80% within 25 s in blood. In the SD rat liver penetrating injury model, compared with commercial medical gelatin sponge and PVA sponge, the PDA-TPI-PU sponge could effectively control the bleeding under the NIR light irradiation and did not cause excessive compression of the wound. The sponge with these characteristics shows potential application prospects as a hemostatic material.

Keywords: Controllable; Incompressible hemorrhage; Polydopamine.

MeSH terms

Animals
Hemorrhage / therapy
Hemostatics*
Polyurethanes* / pharmacology
Rats
Rats, Sprague-Dawley

Substances

polydopamine
Polyurethanes
Hemostatics