Multifunctional nano MOF drug delivery platform in combination therapy

Dongwei Ma; Gang Wang; Jingsheng Lu; Xiaoxuan Zeng; Yanwei Cheng; Zhenwei Zhang; Ning Lin; Qing Chen

doi:10.1016/j.ejmech.2023.115884

Multifunctional nano MOF drug delivery platform in combination therapy

Eur J Med Chem. 2023 Dec 5:261:115884. doi: 10.1016/j.ejmech.2023.115884. Epub 2023 Oct 16.

Authors

Dongwei Ma¹, Gang Wang¹, Jingsheng Lu¹, Xiaoxuan Zeng¹, Yanwei Cheng¹, Zhenwei Zhang², Ning Lin³, Qing Chen⁴

Affiliations

¹ Guangxi Scientific Research Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, 530200, China; Guangxi Zhuang Yao Medicine Center of Engineering and Technology, Nanning, 530200, China.
² College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, 530200, China; Guangxi Zhuang Yao Medicine Center of Engineering and Technology, Nanning, 530200, China.
³ College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, 530200, China; Guangxi Zhuang Yao Medicine Center of Engineering and Technology, Nanning, 530200, China. Electronic address: linning@gxtcmu.edu.cn.
⁴ Guangxi Scientific Research Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, 530200, China; Guangxi Zhuang Yao Medicine Center of Engineering and Technology, Nanning, 530200, China. Electronic address: chenqing@gxtcmu.edu.cn.

PMID: 37862817
DOI: 10.1016/j.ejmech.2023.115884

Abstract

Recent preclinical and clinical studies have demonstrated that for cancer treatment, combination therapies are more effective than monotherapies in reducing drug-related toxicity, decreasing drug resistance, and improving therapeutic efficacy. With the rapid development of nanotechnology, the combination of metal-organic frameworks (MOFs) and multi-mode therapy offers a realistic possibility to further improve the shortcomings of cancer treatment. This article focuses on the latest developments, achievements, and treatment strategies of representative multifunctional MOF combination therapies for cancer treatment in recent years, which include not only bimodal combination therapies, but also multi-modal synergistic therapies, further demonstrating the effectiveness and superiority of the MOF drug delivery systems in cancer treatment.

Keywords: Cancer therapy; Combination therapy; Drug delivery; Metal-organic frameworks.

Publication types

Review

MeSH terms

Combined Modality Therapy
Drug Delivery Systems*
Metal-Organic Frameworks* / pharmacology
Nanotechnology

Substances

Metal-Organic Frameworks