Insight into Hyalomma anatolicum biology by comparative genomics analyses

Jinming Wang; Yijun Chai; Jifei Yang; Kai Chen; Guangyuan Liu; Jianxun Luo; Guiquan Guan; Qiaoyun Ren; Hong Yin

doi:10.1016/j.ijpara.2023.09.003

Insight into Hyalomma anatolicum biology by comparative genomics analyses

Int J Parasitol. 2024 Mar;54(3-4):157-170. doi: 10.1016/j.ijpara.2023.09.003. Epub 2023 Oct 17.

Authors

Jinming Wang¹, Yijun Chai², Jifei Yang², Kai Chen³, Guangyuan Liu², Jianxun Luo², Guiquan Guan⁴, Qiaoyun Ren⁵, Hong Yin⁶

Affiliations

¹ State Key Laboratory for Animal Disease and Prevention, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, Gansu 730046, China. Electronic address: wjm0403@caas.cn.
² State Key Laboratory for Animal Disease and Prevention, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, Gansu 730046, China.
³ Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
⁴ State Key Laboratory for Animal Disease and Prevention, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, Gansu 730046, China. Electronic address: guanguiquan@caas.cn.
⁵ State Key Laboratory for Animal Disease and Prevention, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, Gansu 730046, China. Electronic address: renqiaoyun@caas.cn.
⁶ State Key Laboratory for Animal Disease and Prevention, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, Gansu 730046, China; Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou University, Yangzhou 225009, China. Electronic address: yinhong@caas.cn.

PMID: 37858900
DOI: 10.1016/j.ijpara.2023.09.003

Abstract

Hyalomma anatolicum is an obligatory blood-sucking ectoparasite and contributes to the transmission of Crimean-Congo haemorrhagic fever (CCHF) virus, Theileria spp. and Babesia spp. Progress in exploring the adaptive strategy of this ectoparasite and developing tools to fight it has been hindered by the lack of a complete genome. Herein, we assembled the genome using diverse sources of data from multiple sequencing platforms and annotated the 1.96 Gb genome of Hy. anatolicum. Comparative genome analyses and the predicted protein encoding genes reveal unique facets of this genome, including gene family expansion associated with blood feeding and digestion, multi-gene families involved in detoxification, a great number of neuropeptides and corresponding receptors regulating tick growth, development, and reproduction, and glutathione S-transferase genes playing roles in insecticide resistance and detoxification of multiple xenobiotic factors. This high quality reference genome provides fundamental data for obtaining insights into a variety of aspects of tick biology and developing novel strategies to fight notorious tick vectors of human and animal pathogens.

Keywords: Blood feeding; Comparative genome analyses; Detoxification; Hyalomma anatolicum; Multi-gene family.

MeSH terms

Animals
Genomics
Hemorrhagic Fever Virus, Crimean-Congo* / genetics
Hemorrhagic Fever, Crimean*
Humans
Ixodidae* / genetics
Ticks*