Application of microfluidic technologies in forensic analysis

Yuxin Guo; Xingru Zhang; Haoqing Zhang; Yaoshun Liu; Jianfeng Shi; Haotian Meng; Xin Chen; Qiong Lan; Bofeng Zhu

doi:10.1002/elps.202200268

Application of microfluidic technologies in forensic analysis

Electrophoresis. 2023 Nov;44(21-22):1725-1743. doi: 10.1002/elps.202200268. Epub 2023 Oct 19.

Authors

Yuxin Guo^{1

2}, Xingru Zhang^{1

2

3

4}, Haoqing Zhang^{5

6}, Yaoshun Liu⁷, Jianfeng Shi^{1

2}, Haotian Meng^{1

2}, Xin Chen^{1

2}, Qiong Lan^{3

8}, Bofeng Zhu^{1

3

8}

Affiliations

¹ Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China.
² Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China.
³ Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, P. R. China.
⁴ College of Forensic Medicine, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, P. R. China.
⁵ The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China.
⁶ Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China.
⁷ Ankang Hospital of Traditional Chinese Medicine, Ankang, Shaanxi, P. R. China.
⁸ Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.

PMID: 37857551
DOI: 10.1002/elps.202200268

Abstract

The application of microfluidic technology in forensic medicine has steadily expanded over the last two decades due to the favorable features of low cost, rapidity, high throughput, user-friendliness, contamination-free, and minimum sample and reagent consumption. In this context, bibliometric methods were adopted to visualize the literature information contained in the Science Citation Index Expanded from 1989 to 2022, focusing on the co-occurrence analysis of forensic and microfluidic topics. A deep interpretation of the literature was conducted based on co-occurrence results, in which microfluidic technologies and their applications in forensic medicine, particularly forensic genetics, were elaborated. The purpose of this review is to provide an impartial evaluation of the utilization of microfluidic technology in forensic medicine. Additionally, the challenges and future trends of implementing microfluidic technology in forensic genetics are also addressed.

Keywords: forensic genetics; forensic medicine; microfluidic; µTAS.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Forensic Medicine* / methods
Microfluidics*