Subcutaneous injection of IHP-102 prevents lung vaso-occlusion in sickle cell disease mice

Rikesh K Dubey; Ravi Vats; Tomasz Brzoska; Tomasz W Kaminski; Omika Katoch; Jesus Tejero; Gabriel Njikang; John Paderi; Prithu Sundd

doi:10.3324/haematol.2023.283716

Subcutaneous injection of IHP-102 prevents lung vaso-occlusion in sickle cell disease mice

Haematologica. 2024 Apr 1;109(4):1259-1263. doi: 10.3324/haematol.2023.283716.

Authors

Rikesh K Dubey¹, Ravi Vats², Tomasz Brzoska³, Tomasz W Kaminski¹, Omika Katoch¹, Jesus Tejero⁴, Gabriel Njikang⁵, John Paderi⁵, Prithu Sundd⁶

Affiliations

¹ Thrombosis and Hemostasis Program, VERSITI Blood Research Institute, Milwaukee, WI, USA; Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
² Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA.
³ Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Division of Hematology and Oncology, University of Pittsburgh, Pittsburgh, PA.
⁴ Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
⁵ IHP Therapeutics, San Carlos, CA.
⁶ Thrombosis and Hemostasis Program, VERSITI Blood Research Institute, Milwaukee, WI, USA; Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Sickle Cell Center of Excellence, University of Pittsburgh, Pittsburgh, PA. psundd@versiti.org.

No abstract available

MeSH terms

Anemia, Sickle Cell* / complications
Anemia, Sickle Cell* / drug therapy
Animals
Injections, Subcutaneous
Lung
Mice
Vascular Diseases*

Grants and funding

Funding: This study was supported by the sponsored research agreement with IHP Therapeutics and the NIH-NHLBI R44HL167473 to JP. PS was supported by NIH-NHLBI R01HL128297, R01HL141080, R01HL166345 and American Heart Association 18TPA34170588. RKD was supported by the Keystone Grant from the Histochemical Society. RV was supported by American Heart Association predoctoral fellowship 19PRE34430188. TWK was supported by American Heart Association postdoctoral fellowship AHA828786. TB was supported by American Society of Hematology (ASH) Research Restart Award. The Nikon multiphoton excitation microscopes were funded by NIH grants S10RR028478 and S10OD025041.